Gaa na Ọdịnaya
 
International Parkinson and Movement Disorder Society

Ọgwụ nke na-ebelata ọkwa ígwè na mpaghara ụbụrụ emetụtara nwere ike ime mgbanwe ọrịa na ndị nwere ọtụtụ atrophy sistem.

October 5, 2025

HONOLULU, HAWAII, USA - Achọpụtara ọgwụ a na-enye n'ọnụ iji kesaa ngafe ígwè na mgbakasị ahụ oxidative cell na-ebelata ọrịa na-aga n'ihu nke otutu sistemu atrophy (MSA), dịka nnyocha e wepụtara na International Congress of Parkinson's Disease and Movement Disorders® na Honolulu, Hawaii, USA. 

MSA bụ ọrịa na-aga n'ihu ngwa ngwa nke na-emetụta ọtụtụ sistemu ahụ ma jikọta ya na mkpokọta alfa-synuclein na ụbụrụ. Enweghị ọgwụgwọ ma ọ bụ ọgwụgwọ akwadoro maka MSA, nke na-egosi mkpa ọgwụgwọ nyocha dị ka ATH434. Emebere ATH434 iji belata oke ígwè na nrụgide oxidative, nke achọpụtara na ọ na-enye aka na mkpokọta alpha-synuclein. Site n'ichebe usoro ndị a dị n'okpuru anya, ATH434 nwere ikike na-ekwe nkwa dị ka ọgwụgwọ na-agbanwe ọrịa maka MSA. 

"Nsonaazụ ọmụmụ ihe ndị a bụ ihe ọhụrụ na ihe na-akpali akpali n'ọgụ megide ọrịa nhụjuanya na-adịghị akwụsị akwụsị," ka Peter LeWitt MD, M.Med.Sc., Prọfesọ nke Neurology na Pharmacology na Wayne State University School of Medicine and Sastry Foundation Endowed Chair in Parkinson Disease Research kwuru. “Nrụpụta arụmọrụ a na-akọ mgbe otu afọ ọgwụgwọ ya na onyinye ATH434 na-egosi oge ọhụrụ maka mgbanwe ọrịa nke otutu sistemu atrophy (MSA). 

N'ime ule nke abụọ kpuru ìsì nke abụọ nke Stamler et al., Ndị na-eso nwere MSA nwere ike ime ma ọ bụ ụlọ ọgwụ kwadoro 50 mg ma ọ bụ 75 mg nke ATH434 maka izu 52. E jiri ya tụnyere placebo, otu 50 mg na 75 mg hụrụ ọrịa nnọchite anya na-ebelata 48% na 30% n'otu n'otu. Na mgbakwunye, enwere mbelata ígwè na mpaghara ụbụrụ ọ metụtara dịka substantia nigra, putamen, na globus pallidus. Enweghị nnukwu ihe omume ọjọọ metụtara ATH434. 

"Nso nke nchoputa dị mma a kọrọ na-enyere aka kwado usoro dị mma nke ndu maka ATH434; ya bụ, na ngbanwe ya nke ụbụrụ ígwè metabolism na-ebute mbelata nchịkọta ígwè na mpaghara ụbụrụ MSA metụtara," LeWitt kwuru. "N'elu nke a, ATH434 na-enyo enyo na ọ ga-ebelata mkpokọta pathological nke alpha-synuclein, protein bụ isi nke na-ejikọta na ọganihu nke MSA. Ọ bụ ezie na nchọpụta ọmụmụ a kọrọ na-egosi nsonaazụ dị mma nke ụlọ ọgwụ, foto zuru ezu nke ATH434 dị ka ọgwụgwọ na-ekwe nkwa maka MSA na-echere ihe ngosi zuru ezu nke ọmụmụ ihe na nyocha nke ndị ọgbọ na-eme ka ọ dịkwuo njọ site n'iji nyocha ọha na eze na-emewanyewanyewanye nke MSA. ihe akaebe gbara ọkpụrụkpụ maka itinye aka na ebumnuche ọgwụ ahụ bụ ozi na-agba ume maka obodo zuru ụwa ọnụ nke ndị na-arịa ọrịa a na-enweghị ọgwụgwọ.” 

Ederede n'uju nke abstract dị na mdsabtracts.org. 

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Amegide 2025 MDS International Congress of Parkinson's Disease and Movement Disorders®:  

MDS International Congress bụ mmemme kwa afọ nke izizi iji kwalite ọzụzụ ahụike na sayensị nke ọrịa ngagharị, gụnyere ọrịa Parkinson. Na-akpọkọta puku kwuru puku ndị isi ụlọọgwụ, ndị ọkà mmụta sayensị na ndị ọkachamara ahụike ndị ọzọ si gburugburu ụwa, International Congress ga-ewebata ihe karịrị 1,800 abstracts sayensị wee nye ọgbakọ maka agụmakwụkwọ na imekọ ihe ọnụ na nyocha na ọgwụgwọ ọhụụ. 

Banyere International Parkinson and Movement Disorder Society: 
International Parkinson and Movement Disorder Society® (MDS), otu mba ụwa nke ihe karịrị ndị ụlọ ọgwụ 12,000, ndị ọkà mmụta sayensị, na ndị ọkachamara ahụike ndị ọzọ, raara onwe ha nye iji kwalite nlekọta ndị ọrịa site na agụmakwụkwọ na nyocha. Maka ozi ndị ọzọ gbasara MDS, gaa na www.movementdisorders.org.