Nsonaazụ sitere na ọmụmụ ihe nke abụọ nke Mkpa ọgwụgwọ Tremor na-egosi emelitere ịma jijiji elu elu

Ozugbo tọhapụ
Mgbasa ozi kọntaktị: Erica Halmstad
+ 1 414-276-2145
ehalmstad@movementdisorders.org

MILWAUKEE, WI – Nnyocha ọhụrụ na-egosi nsonaazụ na-ekwe nkwa site na nnwale nke abụọ nke ọgwụ maka ọgwụgwọ nke Tremor dị mkpa, dịka ọmụmụ a na-egosi na MDS Virtual Congress 2.

SAGE-324/BIIB124 bụ ezigbo modulator allosteric na-eme ka ikike nke ndị na-anabata ihe na-eme ihe na-emeghachi omume na mgbaàmà. Mgbochi a na-abawanye ka a na-echepụta iji meziwanye akara ngosi nke Tremor dị mkpa.

N'ime ọmụmụ ihe a, a na-eme nyocha nke 2 nke SAGE-324 / BIIB124 iji nwalee nchekwa, ịdị irè na nnabata nke steroid neuroactive. A na-ekenye ndị ọrịa nwere Tremor dị mkpa na-enweghị usoro ọgwụ ma ọ bụ otu placebo na a na-enyocha oke ịma jijiji site na iji Ntụle Atụmatụ Tremor Rating Assessment Scale (TETRAS) ma tupu na mgbe ọgwụgwọ gasịrị. Achọpụtara ịma jijiji n'elu ka ọ na-ebelata n'ime otu ọgwụgwọ metụtara otu placebo.

Roongroj Bhidayasiri, MD, FRCP, Prọfesọ nke Neurology & Director na Ụlọ Ọgwụ Mahadum Chulalongkorn, kwuru na ọmụmụ ihe ahụ na-ekwu, sị, "Nhọrọ ọgwụgwọ ọhụrụ maka ET echerewo ogologo oge na ọgwụ ndị a kwadoro na-akwado ọnụ nke gụnyere propranolol na primidone. Dị ka GABA-A dysregulation bụ usoro a maara nke ọma na-etinye aka na ET, ọ bụ nhọrọ dị mma maka mmepe ọhụrụ nke nwere ike ime nke ọma maka mmepe nke ET, ọ bụ nhọrọ dị mma maka mmepe ọhụrụ nke nwere ike ime nke ọma n'ọdịnihu. Usoro ọgwụgwọ mbụ ma ọ bụ na-ewere ya dị ka ọgwụgwọ adjuvant SAGE-324 / BIIB124 n'oge na-adịbeghị anya na-anwale na usoro 2, ebe a na-achịkwa placebo, na-egosipụta nsonaazụ dị ịrịba ama na mbelata nke elu ụkwụ ịma jijiji arụmọrụ subscale dị ka TETRAS ihe 4 akara na 1-ọnwa ma e jiri ya tụnyere placebo ndị a n'oge nchoputa, mgbe a na-ekwe nkwa nke 28. gụnyere ọnụ ọgụgụ dị nta nke isiokwu na-enweghị njirimara ịma jijiji na nsonaazụ ejedebere n'otu ọkwa ọkwa Ọzọkwa, ntakịrị ihe ọmụmụ (23.5%) mezuru ọmụmụ ihe na mbido mbụ nke 60 mg, na-ebuli ohere nke ihe ọjọọ na-enweghị ike ịnabata ya na usoro onunu ogwu a. Ntụle nsonaazụ nke onye ọrịa na-akọ) na nyocha ọrụ kwa ụbọchị." Onye edemede nke ọmụmụ ihe bụ Sage Therapeutics na-arụ ọrụ.

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Banyere MDS Virtual Congress 2021: Ndị sonyere nzukọ ahụ na-ezukọ iji mụta nchoputa nyocha kachasị ọhụrụ yana nhọrọ ọgwụgwọ ọgbara ọhụrụ na nsogbu mmegharị, gụnyere ọrịa Parkinson. N'ime ndị dibịa 8,000, ndị ọkà mmụta sayensị na ndị ọkachamara ahụike sitere na mba 100 ga-esonye ihe fọrọ nke nta ka ọ bụrụ ilele ihe karịrị awa 30 nke ọdịnaya mmụta yana abtracts sayensị 1,300 nke ndị ọrụ ibe si gburugburu ụwa nyefee.

Banyere International Parkinson and Movement Disorder Society: International Parkinson and Movement Disorder Society (MDS), otu mba ụwa nke karịrị 11,000 ụlọ ọgwụ, ndị ọkà mmụta sayensị, na ndị ọkachamara ahụike ndị ọzọ, raara onwe ha nye iji kwalite nlekọta ndị ọrịa site na agụmakwụkwọ na nyocha. Maka ozi ndị ọzọ gbasara MDS, gaa na www.movementdisorders.org.