Mwepụta akụkọ: Safety na Biomarker Mmetụta nke Ọgwụgwọ Ọhụrụ maka Ọrịa Parkinson na Mgbanwe GBA
EMBARGOED ruo Mọnde, Septemba 25, 2019
Kpọtụrụ ndị mmekọ: Elizabeth Clausen, + 1 414-276-2145, eclausen@movementdisorders.org
Mmetụta Safety na Biomarker nke Ọgwụgwọ Ọhụrụ maka Ọrịa Parkinson nwere Mgbanwe GBA
Ọ dị mma, FRANCE - Achọpụtara ọgwụgwọ ụlọ ọgwụ ọhụrụ, LTI-291, ka ọ dị mma ma nwee ike ịnabata ya n'etiti ndị ọrịa ọrịa Parkinson (PD) nwere mutation GBA, dịka otu ọmụmụ ewepụtara taa na International Congress of Parkinson's Disease and Movement Disorders®.
Dana C. Hilt na otu ndị na-eme nchọpụta na Cambridge, MA, USA, nyochara nchekwa nchekwa na biomarker mmetụta nke LPI-291, onye na-eme ihe na-eme ka CNS penetrant GCase activator, n'etiti ndị ọrịa PD nwere mgbanwe na GBA gene. Edebanyere ndị ọrịa GBA-PD iri anọ ma nye ha LTI-291 ma ọ bụ placebo maka ụbọchị 28. A na-enyocha mkpụrụ ndụ mononuclear ọbara dị n'akụkụ (PBMCs) na plasma maka mgbanwe glycosphingolipid (GSL) na ụbọchị 6, 14 na 28. Ọ dịghị ihe ọjọọ dị njọ kọrọ na ihe ọjọọ ọ bụla bụ otu na LTI-291 dose otu na placebo. A hụrụ mgbanwe dị ịrịba ama na PDMC GSLs wee kwekọọ na ọgwụ ahụ nwere mmetụta ndu ya bu n'obi na GCase. Ọzọkwa, mmetụta GSL ka ukwuu na ndị ọrịa GBA-PD na-ebu mgbanwe GD na mmụgharị dị nro.
Jean-Christophe Corvol, onye enyemaka Prọfesọ na Neuropharmacology na Pitié-Salpêtrière Hospital na Paris, France na-ekwu, "Mgbanwe na lysosomial enzyme Glucocerebrosidase (GCase) gene (GBA) na-ebute ọrịa Gaucher mgbe ọ dị na steeti homozygous, mana e gosipụtara na ọ na-abawanye ohere nke ọrịa Parkinson-foldus na-ebute ọrịa Parkinson. echiche na ụzọ a na-etinye aka na pathophysiology nke ọrịa ahụ Hilt na ndị na-emekọ ihe ọnụ na-akọ na usoro mbụ nke 6a na-achịkwa placebo na-ahụ maka nchekwa na mmetụta biomarker nke LTI-2, onye na-eme ihe na-eme ka CNS penetrant GCase activator na PD ndị ọrịa nwere GBA mutations na-edozi ngwaahịa ahụ nke ọma na mkpụrụ ndụ glycos. LTI-291 ma e jiri ya tụnyere placebo, achọrọ nyocha ndị ọzọ iji kwado mkpa ahụike nke nchoputa ndị a na ndị ọrịa PD nwere mgbanwe GBA.
Banyere International Congress of Parkinson's Disease and Movement Disorders®: Ndị bịara nzukọ na-ezukọ iji mụta nchoputa nyocha kachasị ọhụrụ yana nhọrọ ọgwụgwọ ọgbara ọhụrụ na Nsogbu Mmegharị, gụnyere ọrịa Parkinson. Ihe karịrị ndị dibịa 5,100 na ndị ọkachamara ahụike sitere na mba 95 ga-abịa na-ekiri ihe odide sayensị 2,200 nke ndị dọkịta si gburugburu ụwa nyefere.
Banyere International Parkinson and Movement Disorder Society:
International Parkinson and Movement Disorder Society (MDS), otu mba ụwa nke ihe karịrị ndị dọkịta 8,500, ndị ọkà mmụta sayensị, na ndị ọkachamara ahụike ndị ọzọ, raara onwe ha nye iji kwalite nlekọta ndị ọrịa site na agụmakwụkwọ na nyocha. Maka ozi ndị ọzọ gbasara MDS, gaa na www.movementdisorders.org.