Gaa na Ọdịnaya
 
International Parkinson and Movement Disorder Society

Ọnwụnwa mmadụ ọhụrụ chọtara A-dopamine na-aga n'ihu na nchịkwa intracerebroventricular dị mma maka ọrịa Parkinson.

PHILADEPHIA, USA -Egosipụta na intracerebroventricular na-aga n'ihu (icv) infusion nke anaerobic dopamine (A-dopamine) dị ka ihe nwere ike ime ma dị mma maka ndị ọrịa na-enwe nsogbu site na ọgwụ dopamine omenala, dịka nchọpụta e wepụtara taa na International Congress of Parkinson's Disease and Movement Disorders.® na Filadelfia.

Nlekọta levodopa na-aga n'ihu, ọgwụgwọ dopaminergic a na-ahụkarị maka ndị ọrịa nwere ọrịa Parkinson, ewepụtala ihe ịma aka dị ka obere ndụ ọkara ndụ, nkesa oke akụkụ, na mmachi nnabata.1 Nlekọta icv na-aga n'ihu nke A-dopamine na-egbochi oxidation dopamine ma egosila na ọ dị mma ma dị irè n'ụdị ọrịa òké na nke na-abụghị nke mmadụ nke ọrịa Parkinson (PD).

Ọmụmụ Moreau et al. gụnyere akụkụ abụọ nke akụkụ. Nkeji 1 kwubiri nchekwa nke ụzọ ahụ. Usoro 2 tụnyere otu ọnwa nke nchịkwa A-dopamine na otu ọnwa nke ọgwụ dopaminergic ọnụ. Ndị na-eso ụzọ 2 niile gosipụtara mbelata dị ukwuu na mmetụta ọgwụ (oge na-adịghị na dyskinesias) na ha enwetaghị dyskinesia butere ma ọ bụ mmetụta ọjọọ.

"Nchọpụta ndị a na-enye ihe akaebe na-egosi na mkpali dopaminergic na-aga n'ihu site na icv A-dopamine nwere ike inye ọganihu dị ukwuu na ahụike ahụike na nkwarụ moto, ikekwe n'ihi mbelata nke nsogbu moto a na-ejikọta ya na ọgwụgwọ ọnụ," Andrew Evans, ọkà mmụta akwara na Royal Melbourne Hospital, kwuru, "N'ụzọ dị ịrịba ama, enweghị dyskinesia na-aga n'ihu A-dopamine infusion nwere ike na-atụ aro na a ga-enwe ike ịmaliteghachi A-dopamine infusion. Sistemụ corticobasal ganglia - isi ihe dị na pathophysiology nke L-dopa kpatara dyskinesia na nsogbu neurobehavioral metụtara ya.

"Ọ bụ ezie na ọmụmụ ihe a dị ntakịrị na ihe ize ndụ dị ogologo oge nke nchịkwa icv A-dopamine na-aga n'ihu na-anọgide na-amaghị, nsonaazụ na-ekwe nkwa na-enye ohere nyocha ọzọ. Usoro akwụkwọ akụkọ a nwere ike na-enye nsonaazụ dị elu ma e jiri ya tụnyere ọgwụgwọ ndị dị ugbu a, dị ka nnyefe nke gel L-dopa na-aga n'ihu na duodenum ma ọ bụ infusions apomorphine subcutaneous."

Ederede n'uju nke abstract a ga-adị na mdsabtracts.org (Ntụaka #675) mgbe mmachi ahụ buliri Septemba 27, 2024, 08:00 ET. 
 

References

  1. Demailly A, Moreau C, Devos D. Ịdị irè nke ọgwụgwọ Dopaminergic na-aga n'ihu na Ọrịa Parkinson: Nyochaa nke L-DOPA Pharmacokinetics/Pharmacodynamics. J Parkinson Dis. 2024;14 (5): 925-939 . doi: 10.3233/JPD-230372. PMID: 38848195; PMCID: PMC11307025.

* * *  

Banyere 2024 MDS International Congress of Parkinson's Disease and Movement Disorders®:  
MDS International Congress bụ mmemme kwa afọ nke izizi iji kwalite ọzụzụ ahụike na sayensị nke ọrịa ngagharị, gụnyere ọrịa Parkinson. Na-akpọkọta puku kwuru puku ndị isi ụlọọgwụ, ndị ọkà mmụta sayensị na ndị ọkachamara ahụike ndị ọzọ si gburugburu ụwa, International Congress ga-ewebata ihe karịrị 1,800 abstracts sayensị ma nye ọgbakọ maka agụmakwụkwọ na imekọ ihe ọnụ na nchoputa nyocha kachasị ọhụrụ na nhọrọ ọgwụgwọ ọgbara ọhụrụ. Mụtakwuo na www.mdscongress.org. 

Banyere International Parkinson and Movement Disorder Society: 
International Parkinson and Movement Disorder Society® (MDS), otu mba ụwa nke ihe karịrị ndị ụlọ ọgwụ 11,000, ndị ọkà mmụta sayensị, na ndị ọkachamara ahụike ndị ọzọ, raara onwe ha nye iji kwalite nlekọta ndị ọrịa site na agụmakwụkwọ na nyocha. Maka ozi ndị ọzọ gbasara MDS, gaa na www.movementdisorders.org.